UHPLC Column, RP PFP, 1.8um, 100A. 4.6mm ID x 150mm Length. Cogent Brand. 1 EA.
Additional Info:
The 68122‑15P Cogent RP PFP™ UHPLC Column is designed for high‑resolution separation of halogenated, aromatic, and polar compounds, delivering enhanced selectivity where conventional C18 phases may not fully resolve analytes.
This stationary phase utilizes a pentafluorophenyl (PFP) ligand bonded via a four‑carbon linker to high‑purity silica with full double end‑capping, providing multiple interaction mechanisms including π‑π interactions, dipole interactions, and hydrogen bonding. These combined mechanisms enable greater selectivity control and improved separation of structurally similar compounds.
This column is well suited as an alternative for USP L43 methods and for advanced method development requiring different retention behavior than traditional reversed‑phase columns
150 mm Length – High Resolution for Analytical Workflows
The 150 mm length delivers significantly greater resolving power than shorter columns, making it ideal for complex separations and high‑precision analytical work.
Higher resolution than 50 mm and 100 mm columns
Improved separation of closely related compounds
Increased peak capacity for complex samples
✅ Use when maximum analytical resolution is required without moving to longer 250 mm columns
Flow Rate & System Requirements (4.6 mm ID, 1.8 µm)
⚠️ Requires UHPLC system capability due to high backpressure
Typical flow rate range: ~1.0–2.0 mL/min
Optimal starting range: ~1.2–1.5 mL/min
Requires stable high‑pressure pump performance
Compatible with standard analytical detectors
✅ Sample preparation requirement: filter samples using a 0.2 µm syringe filter prior to injection
Why Choose PFP for Selective Separations
Enhanced Retention for Halogenated Compounds
Strong interaction with fluorinated and halogenated analytes
Improved selectivity compared to C18
Multiple Interaction Mechanisms
π‑π interactions for aromatic compounds
Dipole and hydrogen bonding interactions
Broader selectivity options in method development
High Resolution for Difficult Separations
Enables separation of structurally similar analytes
Ideal for refining challenging analytical methods
Cogent RP PFP™ Advantages
Fully End‑Capped Surface
Minimizes secondary silanol interactions
Improves peak symmetry for polar compounds
High Efficiency (1.8 µm Particles)
High plate counts and peak capacity
Enables fast, high‑resolution separations
High Purity Silica
Consistent column performance
Reliable reproducibility across methods
Typical Applications
Halogenated compound analysis
Aromatic compound separations
Pharmaceutical QA/QC and development
LC‑MS and HPLC analytical workflows
USP L43 method applications
Important Usage Notes
⚠️ Requires UHPLC system (high pressure capable)
Designed for high‑efficiency analytical workflows
Higher backpressure than larger particle columns
Use 0.2 µm filtration to maintain column performance